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^{A Future Biogas biomethane plant (Photo: Business Wire)}

15-year agreement with Future Biogas will provide 100 GWh of green gas (biomethane) annually, equivalent to meet the heat demands of over 8,000 homes

Initiative will provide additional renewable capacity to the national gas grid, representing the UK’s first fully commercial biomethane system

Significant boost to energy efficiency at UK’s largest medicines manufacturing site in Macclesfield, through upgrade of combined heat and power plant

CAMBRIDGE, United Kingdom, Sept 14 (Bernama-BUSINESS WIRE) — Powering AstraZeneca’s transition to net zero, the Company has agreed a 15-year partnership with Future Biogas to establish the UK’s first unsubsidised industrial-scale supply of biomethane gas, and is investing in major energy efficiencies in its operations, totalling a commitment of £100m.

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Energy from the biomethane facility will supply AstraZeneca’s sites in Macclesfield, Cambridge, Luton and Speke with 100 gigawatt hours (GWh) per year, equivalent to the heat demands of over 8,000 homes.ⁱ Once operational in early 2025, the partnership will reduce emissions by an estimated 20,000 tonnes CO₂ equivalent (CO₂e), adding renewable energy capacity to the national gas grid.

The anaerobic digestion facility and long-term partnership with Future Biogas provide a blueprint for the commercial adoption of renewable gas in the UK. A competitive biomethane market can play a key role in the transition to net zero.ⁱⁱ

To support the transition to clean heat in the UK, energy efficiency improvements will be made at AstraZeneca’s Macclesfield campus, the largest medicines development and manufacturing site in the UK. This includes a major refit of the site’s combined heat and power plant (CHP) which will save a further 16,000 tonnes CO₂e per year, in addition to upgrading buildings and improving the footprint for the production and packing of medicines to enable further greenhouse gas (GHG) reductions. These efficiency projects will support the long-term sustainable operations of the Macclesfield campus, which delivers more than 90 million packs of medicines to more than 130 countries.

The transition to 100% renewable energy is a key element of AstraZeneca’s flagship Ambition Zero Carbon programme, which is focused on delivering deep decarbonisation by halving the company’s entire value chain footprint (Scopes 1 to 3) by 2030 and becoming science-based net zero by 2045 at the latest. AstraZeneca is on track to reduce GHG emissions from its global operations (Scope 1 and 2) by 98% by 2026.

Juliette White, Vice President, Global Sustainability & Safety, Health & Environment, at AstraZeneca, said: “Today’s commitment of £100 million shows we are serious about decarbonising the discovery, development and manufacture of medicines and securing a sustainable future for our sites across the UK and globally. In leading from the front on the commercial adoption of clean heat, we are innovating to expand the usage of renewable energy, contributing to the circular economy and accelerating our progress towards net zero.”

Philipp Lukas, CEO of Future Biogas, said: “AstraZeneca’s ground-breaking investment in green gas affirms its status as a global leader in the transition to net zero. The opportunity to combine unsubsidised biomethane production with regenerative farming benefits local farms and supports the growing focus on soil health and sustainable food production. Future Biogas expects this model to be adopted by many other innovative organisations with strong net zero ambitions.”

The site will utilise locally-grown crops as feedstock and support farms with sustainable land management practices, enabling the development of a circular agricultural economy. Bioenergy crops will be grown as part of diverse crop rotations and will follow regenerative agriculture practices, promoting nutrient cycling and improving soil health.

Renewable Gas Guarantee of Origin (RGGO) certificates will be transferred to AstraZeneca, to ensure there is no double counting of emissions savings.

The new plant will be fitted with bioenergy carbon capture and storage capability (BECCS) which has the potential to enable the carbon negative operation of the plant. AstraZeneca aims to sequester the carbon through the ‘Northern Lights’ project in Norway, a joint venture involving industry and supported by the Norwegian Government.

This latest commitment to renewable energy in the UK follows other innovative partnerships announced earlier this year. In the US, AstraZeneca is partnering with Vanguard Renewables to enable the delivery of biomethane to all its US sites by the end of 2026. The Company has also entered into an agreement with Statkraft, Europe’s largest renewable energy producer, to increase the supply of renewable electricity in Sweden.

Notes

Biogas and biomethaneⁱⁱⁱ

Biogas is produced by the fermentation of organic matter in anaerobic digestion tanks. Biomethane is biogas from which the by-product carbon dioxide has been removed, giving the biomethane the same properties as natural gas, and enabling it to be injected into the national gas grid. In Future Biogas’ plants the feedstocks will have a zero or negative carbon footprint meaning the biomethane is 100% renewable energy, allowing a significant reduction in greenhouse gas emissions.

Energy crops grown for Future Biogas absorb carbon dioxide (CO₂) from the atmosphere during their growth. Once harvested and stored, the energy crops are fed into anaerobic digestion tanks where bacteria break down the organic matter in the absence of oxygen, releasing biogas. The residue is an organic fertiliser (digestate) which in conjunction with changes to the farming rotation helps accelerate soil carbon capture.

Bioenergy with Carbon Capture and Storage (BECCS)^iv

Bioenergy with carbon capture and storage (BECCS) is a carbon removal technique to remove carbon dioxide from the atmosphere. Biomass (organic material) is converted into heat, electricity, or liquid or gas fuels, and the carbon dioxide emissions from this bioenergy conversion are captured and stored in geological formations or embedded in long-lasting products. It does not utilise the injected CO₂ for enhanced oil recovery.

About Future Biogas

Future Biogas is at the forefront of the anaerobic digestion (AD) industry. The company is a highly experienced developer and operator of AD plants across the UK, and able to provide full-service capabilities of development, construction, operations, ongoing compliance and asset management, both to owned projects and to those of third parties. Future Biogas plants convert a wide range of feedstocks into clean, renewable energy, through a process of anaerobic digestion, which produces biogas. Biogas can either be used to generate green electricity or upgraded into biomethane and injected into the UK’s national gas network.

For more information, please visit https://www.futurebiogas.com.*

About Northern Lights

Northern Lights is developing an open and flexible infrastructure to transport CO₂ from industrial emitters by ship to a receiving terminal in western Norway for intermediate storage, before being transported by pipeline for permanent storage in a geological reservoir 2,600 metres under the seabed. Operations are scheduled to start in 2024. The facilities are under construction and will enable Northern Lights to offer a safe and reliable shipping and storage service to industrial emitters from across Europe. With increased interest from industrial sectors in Europe, additional shipping and storage capacity will be developed as demand grows.

For more information, please visit https://northernlightsccs.com/.*

About AstraZeneca

AstraZeneca is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines in Oncology, Rare Diseases, and BioPharmaceuticals, including Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. AstraZeneca operates in over 100 countries and its medicines are used by millions of patients worldwide.

With a proud 100-year heritage in advancing UK science, today AstraZeneca is the UK’s leading biopharmaceutical company. AstraZeneca is based in five different locations across the UK, with its global headquarters in Cambridge. In the UK, around 8,700 employees work in research and development, manufacturing, supply, sales, and marketing. We supply around 35 different medicines to the NHS.

For more information, please visit www.astrazeneca.co.uk and follow us on Twitter @AstraZenecaUK.

References

News Release

1:	Ofgem’s Typical Domestic Consumption Values (TDCVs) of 12,000 kWh for a medium property
2:	Transitioning towards Sustainability – Bioenergy Review (2023) IEA Bioenergy Report 2023.
	Available at: https://www.ieabioenergyreview.org/transitioning-towards-sustainability/ [Last Accessed: 06 September 2023].
3:	IEA (March, 2020) An introduction to biogas and biomethane. Online: https://www.iea.org/reports/outlook-for-biogas-and-biomethane-prospects-for-organic-growth/an-introduction-to-biogas-and-biomethane [Last accessed: 07 September 2023]
4:	IEA (2023) Bioenergy with carbon capture and storage – energy system, IEA. Available at: https://www.iea.org/energy-system/carbon-capture-utilisation-and-storage/bioenergy-with-carbon-capture-and-storage [Last accessed: 07 September 2023].
_________________________________
*AstraZeneca is not responsible for the content on this website.

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Contact

For details on how to contact the Investor Relations Team, please click here. For Media contacts, click here.

Source : AstraZeneca

Data presented by Dr. Dean Fennell in an oral presentation at the IASLC 2023 World Conference on Lung Cancer in Singapore

RS Oncology’s novel therapy RSO-021, a first-in-class inhibitor of the antioxidant protein PRX3, was shown to reverse many of the features associated with aggressive mesothelioma tumor growth

CAMBRIDGE, Mass., Sept 14 (Bernama-BUSINESS WIRE) — RS Oncology, a clinical stage biotechnology company developing innovative therapies to eradicate mesothelioma and other diseases, was part of a collaboration that recently shared new preclinical data at the IASLC 2023 World Conference on Lung Cancer in Singapore. The data, presented by Dr. Dean Fennell, represented a partnership between RS Oncology and other lead research institutions, including the University of Leicester and the Cunniff Laboratory at the University of Vermont Cancer Center.

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Mesotheliomas can transform from a less aggressive epithelioid malignancy to a more aggressive sarcomatoid form. Using biphasic mesotheliomas as a model containing both epithelioid and sarcomatoid features, investigators at the University of Leicester, led by Dr. Fennell, conducted a geospatial analysis of patient tissues to explore the molecular signatures associated with the histological regions.

Using sophisticated spatial analysis tools coupled with machine learning approaches, the group found that the more aggressive sarcomatoid regions had distinct molecular signatures driving pro-tumor pathways, drug resistance, and increased metastatic potential. These findings were validated across an independent cohort of 150 mesothelioma patient tissues. Notably, tumor regions containing sarcomatoid tissue showed features of increased resistance to oxidative stress – a critical tumor cell adaptation for survival.

In collaboration with Dr. Brian Cunniff’s laboratory, the team then evaluated molecular signatures of human biphasic mesothelioma tumor cells following treatment with the irreversible PRX3 inhibitor RSO-021, which is currently being evaluated in a Phase 1/2 clinical trial in patients with malignant pleural effusion caused by advanced/metastatic solid tumors (NCT05278975). RSO-021 treatment reversed the gene signatures associated with epithelial-to-sarcomatoid transition, including downregulation of hypoxia, glycolysis, and epithelial-to-mesenchymal transition (EMT)-associated genes. These results suggest that this transition, thought to be unidirectional in nature, may be PRX3-dependent, druggable, and now reversible.

“Sarcomatoid tumors are highly resistant to anti-cancer therapies, and many patients run out of available treatment options. Our findings might have unveiled a druggable ‘Achilles Heel’ against this terrible disease,” said Dr. Fennell, presenting author on the study. “The ability to treat such tumors with RSO-021 and revert them to epithelioid malignancies could delay or even prevent emergence of the most aggressive features associated with mesothelioma. Further, RSO-021 could potentially sensitize them to other treatments.”

Presentation Details 
Abstract Number: MA17.11 
Session: MA17 – Current Standards and Future Directions in Mesothelioma
Title: Spatial Transformation in Mesothelioma Involves a Hypoxia-TGF Beta-EMT Axis that is Reversible via PRX3 Inhibition 
Date: Tuesday, September 12, 10:45 AM UTC +8

About RS Oncology 
RS Oncology (RSO) is a clinical stage biotechnology company based in Cambridge, Massachusetts with a mission to eradicate mesothelioma and other diseases worldwide through novel science and an innovative business model.

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Contact

Jarrett Duncan, CEO
j.duncan@rsoncology.com

Source : RS Oncology

–BERNAMA

KUALA LUMPUR, Sept 12 (Bernama) — The Pujiang Innovation forum over the past 16 years, has steadily increased its global influence, played a pivotal role in advancing China’s innovation-driven development strategy, scientific self-reliance, self-improvement, and the transformation of Shanghai into a technological innovation hub.

Themed “Fostering an Open Innovation Environment: Innovation and Global Connections”, this year’s forum featured over 300 guests from 31 countries and regions with nearly 40 per cent international participants, was held on Sept 9-11.

According to Shanghai Center for Pujiang Innovation Forum in a statement, it debuted the Global Entrepreneurship Investment Conference, aimed at establishing Shanghai as the premier global destination for technology entrepreneurship investment by facilitating connections between projects and capital.

As an influential innovation forum, it positioned at a new juncture and aspires to become a national-level platform for global scientific and technological innovation exchange, and cooperation.

It is firmly committed to three core missions which are establishing an innovation network, staying attuned to future trends and nurturing young talent.

Meanwhile, its five key roles encompass serving as a wellspring of cutting-edge innovation thinking, a global benchmark for scientific and technological advancement, an accelerator for international scientific and technological collaboration, a magnet for global innovation talent, and a hub for global technology transfer.

All of these efforts align with Shanghai’s vision of evolving into an international epicentre for science and innovation and achieving the goal of becoming a world leader in technology.

Another notable forum event is the Global Technology Transfer Conference, which centres on three core elements comprises innovation demand, talent support and capital strength.

By utilising the InnoMatch global supply and demand platform, the conference included an expansive 10,000 square metre offline exhibition area, showcasing over 3,000 technology requirements and more than 20,000 job opportunities for scientific and technological talents across the nation.

— BERNAMA

Roseau, Sept 11 (Bernama-GLOBE NEWSWIRE) — The Commonwealth of Dominica is a small island located in the Caribbean between Martinique and Guadeloupe. Tourists marvel at the crystal blue ocean views and tropical humid climate, there is an abundance of discovery on the Nature Isle of the Caribbean. 

Explore 30 interesting facts about the magical island of Dominica! 

Cultural history 

1. Dominica was named by Christopher Columbus 

Prior to Christopher Columbus’ arrival on the island, the Caribbean settlers named it Watikbuli, meaning ‘Tall is her Body’. In 1493, Christopher arrived on the island and named it Domingo, which means Sunday, the day which he discovered the island. 

2. Dominica has an interesting motto 

The motto is French, ‘Après le Bon Dieu, c’est la Terre’, translated to English as ‘After God, the Earth’, Dominica eloquently displays its natural beauty. 

3. Dominica is a republic in the Commonwealth 

The Nature Isle gained its independence on 3 November 1978 and celebrates this day annually with vibrant national festivities. These include cultural markets, music festivals, and beauty pageants. 

4. The National Anthem is titled ‘Isle of Beauty, Isle of Splendour’ 

Dominica’s national anthem was written by Wilfred Oscar Morgan, with the music composed by Lemuel McPherson Christian OBE, after receiving statehood in 1967. 

5. Government system 

As a parliamentary democratic republic nation, The Executive branch of government has a President and Prime Minister, whereby nominees are elected in consultation with the opposition leader. The two-party system, with the ruling Dominica Labour Party and the opposition party, the United Worker’s Party. 
All Dominican adult citizens may cast their ballots every five years during the government elections. 

6. Dominica’s President, His Excellency, the Honourable Charles Savarin 

Elected as Dominica’s eighth president in October 2013, Honourable Charles Savarin is a member of the Dominica Labour Party. He received his nomination from Prime Minister, Honourable Roosevelt Skerrit, who has been the head of government since August 2004. Previously, His Excellency, Honourable Savarin was a teacher, trade unionist, parliamentarian, diplomat, and government minister. 

7. English Common Law system 

Dominica’s constitution includes the right to life, personal liberty, and freedom of expression, which follows one-third of the world’s English Common Law. The hierarchy of Dominica’s court starts from the Magistrate Court, High Court, Court of Appeal, and lastly The Court of Appeal the Privy Council. 

8. Dominica’s small population of 72,412 

The population of Dominica is currently sitting at 72,414, making it the 11th least-populated nation in the world.

9. The Dominican flag is one of only two national flags with the colour purple 

Out of all the nations in the world, Dominica’s national flag is one of only two national flags to incorporate the colour purple. The other is the Nicaraguan national flag. The Dominican national flag features a Sisserou Parrot that has purple feathers on the underside and the crown.   

Geographical landscape 

10. The island is also known as the Nature Isle of the Caribbean 

Dominica’s spectacular natural beauty is oftentimes affectionately known as “The Nature Isle of the Caribbean.” The vast amount of the island is covered in lush forests. Year-round visitors can experience wondrous waterfalls and mud ponds. Indigenous rainforest animals and insects such as parrots, iguanas and rare butterflies make up some of the phenomenal fauna.  

11. The national flowers for Dominica 

The Sabinea carinalis, warmly known as the ‘Bwa Kwaib’ or the Carib Wood. Is the indigenous wild xerophytic plant. In bloom, it exhibits bright scarlet flowers from its branches. It is said to represent the longevity of the Dominican youth. 

12. The National Bird of Dominica is the Sisserou Parrot 

The national bird of Dominica the Sisserou (Amazona Imperialis), “The Pride of Dominica” is found on the country’s emblems such as the Coat of Arms, the National Flag, the Public Seal, The Mace of the House of Assembly and Dominica’s Honours for Meritorious Service. The imperial parrot is endemic to Dominica’s dense mountainous rainforests. This shy and yet attractive indigenous bird has resided on the island for numerous thousands of years and can live over 70 years of age. The bird is an endangered species and is under preservation. 

13. Dominica is the only country in the world where sperm whales reside year-round!  

Sperm whales have called Dominica’s waters their home, and it is extremely likely to spot them swimming in pods, as whales and dolphins live close to shore throughout the year.   

14. The Island is home to the Giant Ditch Frog known as the “mountain chicken” 

Dominicans refer to the frog as the “mountain chicken” due to its legs imitating drumsticks. The frog used to be a delicacy as a national dish and is now under conservation to preserve the species. 

15. Home to the Caribbean’s first long-distance hiking trail 

The Waitukubuli National Trail (WNT) is the first long-distance hiking trail in the Caribbean. It is estimated to be 183 km long and is split into 14 sections. The trail was built between 2007 and 2012, the route crosses through Dominica and traverses some of the country’s most spectacular terrain. It will take a minimum of two weeks to complete the hiking trail. 

16. Dominica is home to a UNESCO World Heritage Site 

The Morne Trois Pitons National Park is the exclusive Heritage Site in Dominica and was designated a UNESCO World Heritage Site in 1997. This national park is situated in the southern half of the island and contains many of Dominica’s most spectacular attractions including the Titou Gorge, Boeri, Freshwater Lakes, the Boiling Lake, and the Middleham Falls. The Morne Trois Pitons National Park covers roughly 9 per cent of Dominica’s land area. 

17. Dominica has practised herbal medicine for centuries 

The original inhabitants of the island, the Caribs, and later Africans, brought with them thorough knowledge of plants and herbs. This knowledge has been passed down through generations and many herbs like Moringa, Basil and Dandelion are still used today for medicinal purposes, usually referred to as “bush medicine.” 

Economic features of Dominica 

18. Dominica’s main industries 

The country’s main industries are agriculture, tourism and manufacturing. Over 20 per cent of the island’s land is arable and under cultivation, with bananas traditionally serving as Dominica’s largest export. Although Dominica has recently increased the production of other fruits, as well as vegetables and coffee beans.  
Dominica’s tourism sector continues to steadily grow, with the alluring nature attracting an estimated 200,000 holidaymakers annually. The island’s manufacturing industry primarily depends on raw materials from the agricultural sector, where in-demand exports include coconut soap, ceramics and shoes. 

19. Dominica’s official currency is the East Caribbean Dollar (XCD) 

Dominica introduced the Eastern Caribbean Dollar (ECD) currency in 1965, which is used in another seven countries in the Organisation of Eastern Caribbean States (OECS).  

Foreign currencies including the euro and dollar are also accepted as tender. It is also pegged to the US dollar at a rate of US$1 to ECD (East Caribbean Dollar) $2.70. As Dominica is a member of the Commonwealth, all banknotes and coins feature an image of King Charles III.   

20. The Gross Domestic Product (GDP) Dominica  

The World Bank recorded the island’s GDP had an outstanding US$612,048,148 in financial year 2022. 

21. Investors can acquire Citizenship of Dominica by Investment 

Investors in Dominica tend to seek citizenship through investment opportunities around the country. When visitors officially become Dominican citizens, they can develop businesses, work, relocate and extend their citizenship to their family members. 

Dominica’s CBI Programme received first in the Citizenship by Investment (CBI) initiative for six consecutive years by the CBI Index.  

22. English is Dominica’s official language 

English is universally spoken in Dominica and UK English spelling is used. Dominican Creole (an Antillean Creole derived from French), and French Patois are spoken amongst the locals. This is because of the long history of French migration to the island as well as Dominica’s location between two French-speaking countries; Martinique and Guadeloupe.  

23. Christian religious practices 

Christianity is the most common religion in Dominica, practised by over 90 per cent of the population. However, religious freedom is enshrined in the Constitution of Dominica so inhabitants can follow alternative faiths if they so choose, such as Rastafarianism. 

24. Cricket is the most popular sport in Dominica 

Many Dominican cricketers play for the West Indies cricket team internationally. Shane Shillingford and Adam Sanford are two of the most notable cricketers from Dominica. 

25. The capital city of Dominica is Roseau 

The largest city in Dominica it is located on the Southwest coast of the country and is surrounded by the Caribbean Sea, the Morne Bruce Hill and the Roseau River. Filled with lively markets, 18th-century French architecture and famous landmarks like the Roseau Cathedral and the Morne Bruce Cross.   

26. The Main Airport is Douglas-Charles Airport 

Formerly known as Melville Hall Airport, Douglas–Charles Airport is Dominica’s largest of the country’s two airports. Douglas–Charles Airport operates both passenger and cargo planes to other destinations in the Eastern Caribbean region.   

27. Dominica is on a quest to be the world’s first climate-resilient nation 

The Government of Dominica has called on investors around the world to assist in the development of sustainable and robust industries and infrastructure. This is an exclusive opportunity to implement the latest technologies and developmental approaches. Dominica aims to be at the forefront of tackling climate change challenges. 

28. Unique rivers for each day of the year

Apart from breathtaking beaches and volcanoes, Dominica has over 365 rivers! While some are cool and clear, others are cloudy and fast. All the rivers are surrounded by exotic plants and flowers. The Indian River is the widest on the island, and many visitors choose this river to explore the rivers for the first time. 

29. There are nine active volcanoes in Dominica  

Dominica has the highest concentration of volcanoes in the world, with approximately nine active volcanoes. Eruptions are very rare, and the last volcanic eruption was in 1997 and the one before that was in 1880.  

The highest mountain and volcano are Morne Diablotins, and it is a magical sight. Adventurists can take a six-hour hike to reach the top where neighbouring islands, Martinique and Guadeloupe can be seen from the top. 

30. Many of Dominica’s beaches are covered in black sand 

The volcanoes in Dominica influence the colour of beautiful black-sand beaches. Some of the most famous black sand beaches in Dominica include the Number One Beach, Mero Beach, and Rosalie Bay Beach. 

Secretary of Dominica Citizenship by Investment Programme
Commonwealth of Dominica
001 (767) 266 3919
info@cbiu.gov.dm

SOURCE: Commonwealth of Dominica

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KUALA LUMPUR, Sept 12 (Bernama) — VINSSEN, a maritime technology specialist in eco-friendly vessels and propulsion systems, has been awarded AIP Certification from Korean Register for its in-house developed 100 kilowatts (kW) Marine Fuel Cell Module.

According to a statement, this certification is the first in a four-stage evaluation process for new technologies and is significant as it attests to viability of the design plan by the reputable Korean Register.

This follows VINSSEN’s receipt of Type Approval for its Marine Lithium-Ion Battery System from Korean Register and Korea Maritime Transportation Safety Authority (KOMSA) in 2023.

The 100kW Marine Fuel Cell Module consists of a Fuel Cell Stack and Balance of Plant (BOP) that includes a Hydrogen Supply Device, Air Supply Device, and Cooling Device, among other components.

The company’s Fuel Cell Module uses Proton Exchange Membrane Fuel Cell (PEMFC) technology, which offers advantages in deployment onboard smaller vessels.

It is planning to embark on a “Hydrogen Fuel Cell Based Leisure Vessel Construction, Verification, and Mobile Charging Facility Development Project” by incorporating 2 x 100kW Fuel Cell Modules on a Leisure Vessel, with construction and verification testing scheduled, next year.

With the support of Jeollanam-do Province and Yeongam, VINSSEN will construct Hydrogen Fuel Cell Leisure Vessels in a safe demonstration environment.

VINSSEN will utilise a shipyard near the Daebool National Industrial Complex while establishing and operating a mobile hydrogen charging station equipped with differentiated monitoring technology.

— BERNAMA